Dynamic localization of DNA topoisomerase 1 and its functional relevance during Drosophila development
نویسندگان
چکیده
منابع مشابه
Differential subcellular localization of DNA topoisomerase-1 isoforms and their roles during Caenorhabditis elegans development.
DNA topoisomerase-1 (TOP-1) resolves the topological problems associated with DNA replication, transcription and recombination by introducing temporary single-strand breaks in the DNA. Caenorhabditis elegans TOP-1 has two isoforms, TOP-1α and TOP-1β. TOP-1β is broadly localized to the nuclei of many cells at all developmental stages and concentrated in nucleoli in embryo gut and oogenic cells. ...
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Developmental regulation of Drosophila DNA topoisomerase II
Affinity-purified polyclonal antibodies were used to quantitate steady-state levels of DNA topoisomerase II (topo II) throughout Drosophila development. Although wide fluctuations were recorded at different stages, these fluctuations were paralleled by changes in levels of the nuclear lamin, a nuclear structural protein used as an internal standard. The exception to this was adult males where l...
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ژورنال
عنوان ژورنال: G3 Genes|Genomes|Genetics
سال: 2021
ISSN: 2160-1836
DOI: 10.1093/g3journal/jkab202